反应详情

A mixture of 7-[2-(2-formamidothiazol-4-yl)-2-(2-formyloxyethoxyimino)acetamido]-3-methyl-3-cephem-4-carboxylic acid (syn isomer, 2.0 g.), conc. hydrochloric acid (1.35 g.), methanol (20 ml.) and tetrahydrofuran (20 ml.) was stirred at room temperature for 6 hours. After evaporating the reaction mixture in vacuo, the residue was subjected to column chromatography on non-ionic adsoption resin "Diaion HP-20" (trademark, manufactured by Mitsubishi Chemical Industries Ltd.) and eluted with 20% isopropyl alcohol. The eluate was concentrated in vacuo to give 7-[2-(2-aminothiazol-4-yl)-2-(2-hydroxyethoxyimino)acetamido]-3-methyl-3-cephem-4-carboxylic acid (syn isomer, 0.8 g.).

1. customAfter evaporating the reaction mixture in vacuo
2. wash" (trademark, manufactured by Mitsubishi Chemical Industries Ltd.) and eluted with 20% isopropyl alcohol
3. concentrationThe eluate was concentrated in vacuo