HRID255774

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCCCCCn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCC#N)c3csc(NC=O)n3)[C@H]2SC1

HCID131715301

未命名化合物

PRODUCTS

生成物

结构：CCCCCCn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCC#N)c3csc(N)n3)[C@H]2SC1

HCID131715302

未命名化合物

收率 70.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A solution of 7-[2-(2-formamidothiazol-4-yl)-2-cyanomethoxyiminoacetamido]-3-(1-n-hexyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 1.11 g.) and conc. hydrochloric acid (0.73 g.) in methanol (11 ml.) and tetrahydrofuran (5 ml.) was treated in a similar manner to that of Example 9-(2) to give 7-[2-(2-aminothiazol-4-yl)-2-cyanomethoxyiminoacetamido]-3-(1-n-hexyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 0.75 g.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fe91541b953742eda50c4dea3691cbe2
来源数据集: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04698337
来源说明: uspto-grants-1987_10

反应 SMILES

C([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:38][O:39][CH2:40][C:41]#[N:42])[C:10]([NH:12][CH:13]2[C:36](=[O:37])[N:15]3[C:16]([C:33]([OH:35])=[O:34])=[C:17]([CH2:20][S:21][C:22]4[N:26]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[N:25]=[N:24][N:23]=4)[CH2:18][S:19][C@H:14]23)=[O:11])[N:8]=1)=O.Cl>CO.O1CCCC1>[NH2:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:38][O:39][CH2:40][C:41]#[N:42])[C:10]([NH:12][CH:13]2[C:36](=[O:37])[N:15]3[C:16]([C:33]([OH:35])=[O:34])=[C:17]([CH2:20][S:21][C:22]4[N:26]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[N:25]=[N:24][N:23]=4)[CH2:18][S:19][C@H:14]23)=[O:11])[N:8]=1