2-Amino-4-methylpyridine → 4-Methyl-2-phthalimidopyridine

HRID 255951Notes

Reaction equation

HRID 255951 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8](Cl)(Cl)Cl)[CH:5]=[CH:4][N:3]=1.NC1C=C(C)C=CN=1.[C:20]1(=O)[O:25][C:23](=[O:24])[C:22]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:21]12>>[CH3:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:1]2[C:23](=[O:24])[C:22]3=[CH:26][CH:27]=[CH:28][CH:29]=[C:21]3[C:20]2=[O:25])[CH:7]=1

Participants

4

Reactant 3

HCID 15332-Amino-4-methylpyridineHCID 6811Phthalic AnhydrideHCID 137101174-(Trichloromethyl)pyridin-2-amine

Product 1

HCID 109990494-Methyl-2-phthalimidopyridine

Procedure

A process for the preparation of 2-amino-4-trichloromethylpyridine of the formula I, wherein 2-amino-4-picoline is reacted with phthalic anhydride to give 4-methyl-2-phthalimidopyridine, the latter is chlorinated and the product is hydrolyzed.

Sources & evidence

ORD record
ord-109dcc2773f8420f9acc4994d6793d4d
Source dataset
uspto-grants-1987_10
Patent number
US04699983

Reaction notes

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