Acetone → HCID 21276139, compound

HRID 256149Notes

Reaction equation

HRID 256149 reaction equation
Br[CH2:2][CH2:3][CH2:4][Cl:5].[C:6]1([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.CC(C)=[O:20]>[OH-].[Na+]>[Cl:5][CH2:4][CH2:3][CH2:2][O:20][N:15]1[CH2:16][CH2:17][N:12]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 180AcetoneHCID 70961-PhenylpiperazineHCID 80061-Bromo-3-chloropropane

Product 1

HCID 21276139HCID 21276139, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

N1 -(3-chloropropoxy)N4 -phenylpiperazine was prepared as described in Ind. J. Chem. 435 (1982) by adding dropwise 87 g (0.55 mole) of 1-bromo-3-chloropropane to a stirred solution of 81 g (0.5 mole) of N-phenylpiperazine in 100 ml acetone and 75 ml of 25% aqueous sodium hydroxide. The organic layer was separated, concentrated, slurried with ethyl acetate, washed, dried over magnesium sulfate, and concentrated to an oil weighing 85 g and analyzed by thin layer chromatography and mass spectrometry to be the title compound.

Workup

  1. customThe organic layer was separated
  2. concentrationconcentrated, slurried with ethyl acetate
  3. washwashed
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated to an oil

Sources & evidence

ORD record
ord-dcbb3a3d337642deaabad75dd5c3c433
Source dataset
uspto-grants-1987_10
Patent number
US04701456

Reaction notes

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