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HRID25648

反应详情

EQUATION

反应方程式

HRID 25648 的结构方程式

REACTANTS

反应物

2
结构：[I-].[Na+]
HCID5238

Sodium Iodide

INa

结构：CN([C@H]1CC[C@H](C#CCCCCl)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1
HCID178484793

未命名化合物

PRODUCTS

生成物

1
结构：CN([C@H]1CC[C@H](C#CCCCI)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1
HCID178484794

未命名化合物

收率 109%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCC(C)=O
溶剂HCID6569

Methyl ethyl ketone

C4H8O

CONDITIONS

反应条件

温度
80 °C

PROCEDURE

实验过程

A solution of 250 mg (0.59 mmol) of trans-N-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide in 10 ml butan-2-one was treated with 136 mg of NaI (0.91 mmol) and heated at 80° C. for 48 h. Evaporation gave 330 mg of crude trans-N-[4-(5-Iodo-pent-1-ynyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide which was used directly for the next step, MS: 514 (MH+).

WORKUP

后处理

  1. customEvaporation