Hydrochloric Acid → HCID 19785042, compound

HRID 256515Notes

Reaction equation

HRID 256515 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][C:6]([CH3:13])=[CH:7][C:8]=2[CH3:12])[N:3]=1.[S:14]([O-:17])([O-:16])=[O:15].[Na+].[Na+].Cl>O>[OH:17][S:14]([C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][C:6]([CH3:13])=[CH:7][C:8]=2[CH3:12])[N:3]=1)(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24437Sodium SulfiteHCID 2732727-Chloro-2,4-dimethyl-1,8-naphthyridine

Product 1

HCID 19785042HCID 19785042, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9.6 g (50 mmol) of 2-chloro-5,7-dimethyl-1,8-naphthyridine prepared in accordance with Lit.8),9) is introduced into a solution of 8.2 g (65 mmol) of sodium sulfite in 40 ml of water which has been adjusted to a pH of 7-8 with dilute aqueous hydrochloric acid. The suspension which is obtained is heated for 12 hours under reflux. After cooling, solid residues are removed from the solution and the solution itself is acidified with aqueous hydrochloric acid (pH about 1). The acidified solution is left for 12 hours at 0° to 5° C., the product crystallizing out. There is obtained 7.7 g (65%) of the title compound; m.p.: >280° C.

Workup

  1. customThe suspension which is obtained
  2. temperatureis heated for 12 hours
  3. temperatureunder reflux
  4. temperatureAfter cooling
  5. customsolid residues are removed from the solution
  6. customthe product crystallizing out

Sources & evidence

ORD record
ord-e3f6728eb2854bb391b17a5ddccb668c
Source dataset
uspto-grants-1993_11
Patent number
US05258356

Reaction notes

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