Styrene Oxide → HCID 19785211, compound

HRID 256530Notes

Reaction equation

HRID 256530 reaction equation
[C:1]1([S:7]([N:10]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][NH2:17])=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:18]1[O:26][CH:19]1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(#N)C>[OH:26][CH:19]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:18][NH:17][CH2:16][CH2:15][C:12]1[CH:13]=[CH:14][N:10]([S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:8])=[O:9])[CH:11]=1

Participants

4

Reactant 2

HCID 7276Styrene OxideHCID 19785210HCID 19785210, compound

Product 1

HCID 19785211HCID 19785211, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 2-(1-phenylsulphonyl-3-pyrrolyl)ethylamine (1.8 g), styrene oxide (0.51 g) and acetonitrile (20 ml) were refluxed for three days. The solution was evaporated and the brown oil was purified by chromatography on silica, eluting with dichloromethane, chloroform then with increasing amounts of methanol (1→10%) in chloroform, to give the title product as a brown oil.

Workup

  1. temperaturewere refluxed for three days
  2. customThe solution was evaporated
  3. customthe brown oil was purified by chromatography on silica
  4. washeluting with dichloromethane, chloroform

Sources & evidence

ORD record
ord-f8b98f00d24948a5ba76f772092d31ce
Source dataset
uspto-grants-1993_11
Patent number
US05258378

Reaction notes

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