Styrene Oxide → HCID 19785208, compound

HRID 256531Notes

Reaction equation

HRID 256531 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:9]=[CH:8][N:7]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)(=[O:12])=[O:11])[CH:6]=1.[CH2:19]1[O:27][CH:20]1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(#N)C>[OH:27][CH:20]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:19][N:2]([CH2:3][CH2:4][C:5]1[CH:9]=[CH:8][N:7]([S:10]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH:6]=1)[CH3:1]

Participants

4

Reactant 2

HCID 7276Styrene OxideHCID 19785209HCID 19785209, compound

Product 1

HCID 19785208HCID 19785208, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of N-methyl-2-(1-phenylsulphonyl-3-pyrrolyl)ethylamine (4 g), styrene oxide (2.06 g) and acetonitrile (50 ml) were refluxed for 2 days. The solution was evaporated and the brown oil was purified by chromatography on silica, eluting with dichloromethane, chloroform then with increasing amounts of methanol (1→25%) in chloroform to give the title product as a brown oil.

Workup

  1. temperaturewere refluxed for 2 days
  2. customThe solution was evaporated
  3. customthe brown oil was purified by chromatography on silica
  4. washeluting with dichloromethane, chloroform

Sources & evidence

ORD record
ord-63bd212717c74b53b32b1480fba84c1d
Source dataset
uspto-grants-1993_11
Patent number
US05258378

Reaction notes

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