1-Cyclopropylpiperazine → HCID 15018100, compound

HRID 256548Notes

Reaction equation

HRID 256548 reaction equation
[CH:1]1([N:4]2[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3][CH2:2]1.[C:10]([CH2:13][C@@H:14]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])(O)=[O:11]>>[CH2:25]([C@H:14]([CH2:13][C:10]([N:7]1[CH2:8][CH2:9][N:4]([CH:1]2[CH2:3][CH2:2]2)[CH2:5][CH2:6]1)=[O:11])[C:15]([O:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:16])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 47420041-CyclopropylpiperazineHCID 14213081(R)-2-Benzyl-succinic acid 1-benzyl ester

Product 1

HCID 15018100HCID 15018100, compound

Procedure

Using the mixed anhydride coupling procedure of Example with 1-cyclopropylpiperazine and benzyl (2R)-3-carboxy-2-benzylpropionate (Rosenberg et al., EP 307837, 1989) gave the desired product. 1H NMR (CDCl3) 7.10-7.34 (m, 5H), 5.11 (dd, 2H), 3.51 (m, 2H), 3.31 (m, 3H), 3.04 (dd, 1H), 2.74 (m, 2H), 2.52 (m, 3H), 2.35 (dd, 1H), 0.47 (m, 2H), 0.42 (m, 2H).

Sources & evidence

ORD record
ord-a892e383a27c45789da35abd95de55c0
Source dataset
uspto-grants-1993_11
Patent number
US05258362

Reaction notes

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