反应详情

温度

25 °C

To a sodium ethoxide solution, which was prepared from sodium (2.11 g) and ethanol (400 ml), were added in turn 2-benzyloxycarbonylamino-2-cyanoacetic acid ethyl ester (24.0 g) and ethyl bromoacetate (15.3 g). The resulting mixture was stirred at 25° C. for 3 hours and concentrated under reduced pressure. The residue was diluted with water and extracted with chloroform. The extracts were washed with water, dried over anhydrous sodium sulfate, and evaporated under reduced pressure to give the title compound (31.6 g, 99%) as a colorless oil.

1. concentrationconcentrated under reduced pressure
2. additionThe residue was diluted with water
3. extractionextracted with chloroform
4. washThe extracts were washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated under reduced pressure