反应详情

20.00 Grams of the 2-chloroallyl-n-hexylcarbinol obtained above were dissolved in 200 g of N,N-dimethylformamide, and 8.39 g of sodium hydroxide in a flake form were added. The resultant mixture was stirred at 25° C. for 10 hours. After the reaction was completed the reaction mixture was neutralized with concentrated hydrochloric acid, and insolubles were filtered off. After the filtrate was concentrated under reduced pressure, the concentration residue was subjected to extraction with toluene, washed with a 7% sodium carbonate aqueous solution and then dried over sodium sulfate. The desiccant was filtered off, and the toluene was distilled off. The resultant oily substance was distilled under reduced pressure to give 15.70 g of n-hexylpropargylcarbinol. The results were as follows.

1. filtrationwere filtered off
2. concentrationAfter the filtrate was concentrated under reduced pressure
3. extractionthe concentration residue was subjected to extraction with toluene
4. washwashed with a 7% sodium carbonate aqueous solution
5. dry with materialdried over sodium sulfate
6. filtrationThe desiccant was filtered off
7. distillationthe toluene was distilled off
8. distillationThe resultant oily substance was distilled under reduced pressure