Potassium Carbonate → HCID 19784262, compound

HRID 256827Notes

Reaction equation

HRID 256827 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]3[C:20]4[CH:21]=[CH:22][C:23]([C:25]([F:28])([F:27])[F:26])=[CH:24][C:19]=4[S:18][C:17]3=[N:29]C(=O)C(F)(F)F)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH:29]=[C:17]1[N:16]([CH2:15][CH2:14][N:11]2[CH2:10][CH2:9][N:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[CH2:13][CH2:12]2)[C:20]2[CH:21]=[CH:22][C:23]([C:25]([F:28])([F:27])[F:26])=[CH:24][C:19]=2[S:18]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 19784270HCID 19784270, compound

Product 1

HCID 19784262HCID 19784262, compoundYield 77.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using the procedure described in example 19 but starting with 3-{2-[4-(4-fluorophenyl)-1-piperazinyl]ethyl}-2-trifluoroacetylimino-6-trifluoromethylbenzothiazoline (3.5 g), a 7% strength aqueous alcoholic solution (15 cc) of potassium carbonate and methanol (150 cc). 2-imino-3-{2-[4-(4-fluorophenyl)-1-piperazinyl]ethyl}-6-trifluoromethylbenzothiazoline (2.2 g) m.p. 250° C. is obtained.

Sources & evidence

ORD record
ord-2ab4fd29fd08470282dfc73f58ff8b42
Source dataset
uspto-grants-1993_11
Patent number
US05260297

Reaction notes

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