反应详情

The compound obtained above in part (a), (30.85 g, 90 mmoles), is dissolved in 100 ml of dry THF and then treated with 2.7 g (90 mmoles) of sodium hydride (80% in oil) which is added in small fractions. At the end of the addition, the mixture is stirred for 30 minutes at ambient temperature. 12.8 g (90 mmole) of methyl iodide are then added and this mixture is stirred for 2 hours at 20° C. The solvent is evaporated and the residue is purified by chromatography on a silica column (eluant: a mixture of dichloromethane, 40% and hexane, 60%).

1. additionis added in small fractions
2. additionAt the end of the addition
3. stirringthis mixture is stirred for 2 hours at 20° C
4. customThe solvent is evaporated
5. customthe residue is purified by chromatography on a silica column (eluant
6. additiona mixture of dichloromethane, 40% and hexane, 60%)