HCID 19784370, compound → HCID 19784344, compound

HRID 257082Notes

Reaction equation

HRID 257082 reaction equation
Cl.Cl.[C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH:14]([N:17]([CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([N+:27]([O-])=O)=[CH:23][CH:22]=3)[CH3:18])[CH2:13][CH2:12]2)=[CH:7][CH:6]=1)#[N:4]>O1CCCC1>[NH2:27][C:24]1[CH:25]=[CH:26][C:21]([CH2:20][CH2:19][N:17]([CH:14]2[CH2:13][CH2:12][N:11]([C:8]3[CH:7]=[CH:6][C:5]([C:3]#[N:4])=[CH:10][CH:9]=3)[CH2:16][CH2:15]2)[CH3:18])=[CH:22][CH:23]=1

Participants

3

Reactant 1

HCID 19784370HCID 19784370, compound

Product 1

HCID 19784344HCID 19784344, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.2 g (3.3 mmol) of the product from Example 2 were hydrogenated on Pd/C (10%) in 100 ml of tetrahydrofuran and worked up in a conventional manner. 1.1 g of 4-(2-(4-aminophenyl)-N-methylethylamino)-1-(4-cyanophenyl)piperidine were obtained as an oil. 1H NMR (d6 -DMSO) δ=1.2-1.5 (2H); 1.8-1.9 (2H); 2.1 (3H); 2.4-2.7 (4H); 2.7-2.9 (2H); 3.3 (1H); 3.9 (2); 6.4 (2H); 6.8 (2H); 6.9 (2H) and 7.5 (2H) ppm.

Sources & evidence

ORD record
ord-db72546422d14e18a42d1022fb3222cd
Source dataset
uspto-grants-1993_11
Patent number
US05260318

Reaction notes

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