Triethylsilane → HCID 19784361, compound

HRID 257091Notes

Reaction equation

HRID 257091 reaction equation
[C:1]([CH:4]([CH:6]([C:8]([OH:10])=[O:9])O)O)([OH:3])=[O:2].[CH2:11]([N:18]([CH:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:31]=[CH:30][C:29]([CH2:32]O)=[CH:28][CH:27]=2)[CH2:22][CH2:21]1)[CH3:19])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C([SiH](CC)CC)C>C(O)(=O)C>[C:8]([OH:10])(=[O:9])/[CH:6]=[CH:4]/[C:1]([OH:3])=[O:2].[CH2:11]([N:18]([CH:20]1[CH2:21][CH2:22][N:23]([C:26]2[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=2)[CH2:24][CH2:25]1)[CH3:19])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 12052TriethylsilaneHCID 19784357HCID 19784357, compound

Product 1

HCID 19784361HCID 19784361, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.9 g (6.1 mmol) of the base of the product from Example 23 were reduced with 1.1 g (9.2 mmol) of triethylsilane and 8.0 g of glacial acetic acid in a similar manner to Example 14. 2.0 g of 4-(N-benzyl-N-methylamino)-1-(4-tolyl)piperidine fumarate were obtained. Melting point 161°-163° C.

Sources & evidence

ORD record
ord-477505b97f83452280cdd3f35a040b14
Source dataset
uspto-grants-1993_11
Patent number
US05260318

Reaction notes

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