3,4-Dimethylpyridine → 1-(3-Chlorophenyl)-4-(3-methyl-4-pyridyl) butane

HRID 257486Notes

Reaction equation

HRID 257486 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8].Br[CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=1>>[Cl:19][C:15]1[CH:14]=[C:13]([CH2:12][CH2:11][CH2:10][CH2:8][C:7]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=2[CH3:1])[CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 114173,4-DimethylpyridineHCID 140848601-(3-Bromopropyl)-3-chlorobenzene

Product 1

HCID 148837941-(3-Chlorophenyl)-4-(3-methyl-4-pyridyl) butaneYield 45.7%

Procedure

1.0 g (9.35 mmol) of 3,4-dimethylpyridine and 2.18 g (9.35 mmol) of 1-bromo-3-(3-chlorophenyl)-propane were reacted in the same manner as in Example 26. The reaction product was purified to obtain 1.11 g of the desired compound (yield: 5.9%).

Workup

  1. customThe reaction product was purified

Sources & evidence

ORD record
ord-06c1c521d1b5456fa9c2c71a0f15490f
Source dataset
uspto-grants-1993_11
Patent number
US05262420

Reaction notes

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