反应详情

12.5 ml of a 1.6-molar solution of n-butyllithium in hexane is added dropwise at 0° C. to a mixture of 0.02 mol of 1,2-difluorobenzene, 0.02 mol of trimethylchlorosilane and 25 ml of THF. After stirring at room temperature for 1.5 hours, the reaction mixture is poured into water, the phases are separated, and the aqueous phase is extracted with 2×50 ml of methylene chloride. Drying over magnesium sulfate, evaporation of the solvent and chromatography give the pure product.

1. customthe phases are separated
2. extractionthe aqueous phase is extracted with 2×50 ml of methylene chloride
3. dry with materialDrying over magnesium sulfate, evaporation of the solvent and chromatography
4. customgive the pure product