Methylamine → 2-Chloro-N-methylpyrimidin-4-amine

Temperature

5 °C

To a solution of 17.0 g (0.11 mole) of 2,4-dichloropyrimidine in 150 ml of dichloromethane was added methylamine (0.25 mole, 20 ml of 40% methanol solution) at such a rate that the temperature of the solution was maintained at 5° C. After the addition, the solution was stirred at room temperature for 12 hours. The reaction mixture was concentrated under reduced pressure, and extracted with dichloromethane. The dichloromethane layer was dried over an anhydrous sodium sulfate, and concentrated under reduced pressure to give 14.0 g (purity 80%) of 2-chloro-4-methylaminopyrimidine.

1. additionAfter the addition
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. extractionextracted with dichloromethane
4. dry with materialThe dichloromethane layer was dried over an anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure

ORD record

ord-892d92912e2e4733995cfdea5ed673ca

Source dataset

uspto-grants-1993_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05264435