p-Toluenesulfonic acid → HCID 19781549, compound

HRID 257754Notes

Reaction equation

HRID 257754 reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[N:33]=[CH:34][C:35]4[CH2:40][C:39](=[O:41])[N:38]([CH3:42])[C:36]=4[N:37]=3)[CH2:28][CH2:27]2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:15][CH:14]=1>C(OCC)(=O)C.CO>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[N:33]=[CH:34][C:35]4[CH2:40][C:39](=[O:41])[N:38]([CH3:42])[C:36]=4[N:37]=3)[CH2:28][CH2:27]2)[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[CH:15][CH:14]=1.[CH3:11][C:1]1[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 15170434HCID 15170434, compound

Product 1

HCID 19781549HCID 19781549, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent2×

Procedure

An ethyl acetate/methanol solution of 0.13 g (0.75 mmole) of p-toluenesulfonic acid was added to an ethyl acetate/methanol solution of 0.31 g (0.75 mmole) of 2-(4-(α(4-methylphenyl)benzyl)piperazino)-5,6-dihydro-7-methyl-6-oxo(7H)pyrrolo[2,3-d]pyrimidine, and the mixture was stirred at room temperature for 1 hour. The solvents were then evaporated under reduced pressure, and the residue was washed with hexane to give 0.36 g (yield 81%) of the desired compound.

Workup

  1. customThe solvents were then evaporated under reduced pressure
  2. washthe residue was washed with hexane

Sources & evidence

ORD record
ord-98d243de5ed940a89f33a9f1ec4e9573
Source dataset
uspto-grants-1993_11
Patent number
US05264435

Reaction notes

Loading…