反应详情

The 2-(3-nitroanilino)-3-chloroformylpyridine was dissolved in tetrahydrofuran (2000 ml) and 70 ml of 30% solution of NH4OH was added dropwise with stirring to the reaction mixture. The reaction mixture was stirred at room temperature for 18 hours. Water was added to the mixture to dissolve the solid ammonium chloride that was formed. The tetrahydrofuran was removed, and the resulting aqueous slurry was filtered and washed yielding a yellow solid. The solid was washed with water and air dried yielding 64.8 g (250 mmole, 99% yield) of 2-(3-nitroanilino)-3-carbamoylpyridine (mp 240°-241° C.).

1. stirringThe reaction mixture was stirred at room temperature for 18 hours
2. customwas formed
3. customThe tetrahydrofuran was removed
4. filtrationthe resulting aqueous slurry was filtered
5. washwashed
6. customyielding a yellow solid
7. washThe solid was washed with water and air
8. customdried