反应详情

A 2 L flask was equipped with a mechanical stirrer, a reflux condenser and a stopper, then charged with 50.05 g (0.329 mol) of methyl 4-hydroxybenzoate, 960 mL of acetone, 22.50 g (1.625 mol) of anhydrous potassium carbonate, 80.5 mL (112.6 g, 0.932 mol) of allyl bromide and the mixture was stirred and refluxed for 14 hours. The mixture was cooled to room temperature, filtered and concentrated to an oil. The residual oil was purified by distillation (97° C. @ 0.03 mm Hg) to afford 53.52 g (86%) of the title compound.

1. customA 2 L flask was equipped with a mechanical stirrer, a reflux condenser
2. temperaturerefluxed for 14 hours
3. filtrationfiltered
4. concentrationconcentrated to an oil
5. distillationThe residual oil was purified by distillation (97° C. @ 0.03 mm Hg)