反应详情

To a solution of 5.168 g (26.9 mml) of the product of Step B in 50 mL of dichloromethane was added 4.40 mL (2.95 mmol) of triethylamine, 4.46 g (2.95 mmol) of tert-butyldimethylchlorosilane, 0.100 g of 4-dimethylaminopyridine, and the reaction mixture was stirred at room temperature for 2 hours. The mixture was then diluted with 50 mL dichloromethane, washed with 100 mL 1 N hydrochloric acid, dried (MgSO4), filtered and evaporated. The residual oil (7.993 g, 97%) was used in the next step without further purification.

1. washwashed with 100 mL 1 N hydrochloric acid
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. customevaporated
5. customThe residual oil (7.993 g, 97%) was used in the next step without further purification