Sodium Hydroxide → Sodium 2-chlorohypoxanthine hydrate

HRID 258070Notes

Reaction equation

HRID 258070 reaction equation
[Na:1].ClC1NC(=[O:12])C2NC=NC=2N=1.O.Cl.[Cl:15][C:16]1[NH:17][C:18](=[O:25])[C:19]2[NH:20][CH:21]=[N:22][C:23]=2[N:24]=1.[OH-].[Na+]>O>[OH2:12].[Cl:15][C:16]1[NH:17][C:18](=[O:25])[C:19]2[NH:20][CH:21]=[N:22][C:23]=2[N:24]=1.[Na:1]

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 5360545SodiumHCID 1354217922-ChlorohypoxanthineHCID 1355888212-Chlorohypoxanthine hydrochloride monohydrate

Product 1

HCID 136331507Sodium 2-chlorohypoxanthine hydrate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In order to prepare the sodium salt of 2-chlorohypoxanthine in highly pure form, 2-chloro-hypoxanthine-hydrochloride-monohydrate is suspended in water. Whilst cooling, the pH is adjusted to a value in the range from 9 to 10, preferably, 9.5 to 10, and more preferably, 9.7, using an aqueous solution of an inorganic base, preferably a solution of an alkali metal hydroxide and more preferably using concentrated sodium hydroxide solution.

Workup

  1. temperatureWhilst cooling

Sources & evidence

ORD record
ord-34fe48501f9446a6a5e3d3e7de6879eb
Source dataset
uspto-grants-1993_11
Patent number
US05264573

Reaction notes

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