反应详情

A mixture of (3RS)-1,3-dihydro-5-phenyl-3-phthalimido-2H-1,4-benzodiazepine-2-one (8.2 g), hydrazine hydrate (1.08 g) and tetrahydrofuran (160 ml) was stirred for 1.0 hour at room temperature and heated under reflux for 1.5 hours. After the precipitates were filtered off, the filtrate was evaporated to small volume and the equivalent volume of diisopropyl ether was added thereto. The precipitates were collected by filtration to give (3RS)-1,3-dihydro-3-amino-5-phenyl-2H-1,4-benzodiazepine-2-one (3.64 g).

1. temperatureheated
2. temperatureunder reflux for 1.5 hours
3. filtrationAfter the precipitates were filtered off
4. customthe filtrate was evaporated to small volume
5. additionthe equivalent volume of diisopropyl ether was added
6. filtrationThe precipitates were collected by filtration