Potassium Acetate → HCID 20373037, compound

HRID 258546Notes

Reaction equation

HRID 258546 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12](=[O:15])[N:13]=[N:14][C:10]3=[CH:9][C:8](=[O:16])[N:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1.[C:24]([O-])(=O)[CH3:25].[K+]>BrC1C=CC=CC=1.C(Cl)Cl.[Cu]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12](=[O:15])[N:13]([C:25]4[CH:24]=[CH:6][CH:23]=[CH:2][CH:3]=4)[NH:14][C:10]3=[CH:9][C:8](=[O:16])[N:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1

Participants

6

Reactant 2

HCID 517044Potassium AcetateHCID 20373035HCID 20373035, compound

Product 1

HCID 20373037HCID 20373037, compound

Reagents, catalysts & solvents 3

HCID 23978CopperCatalystHCID 6344DichloromethaneSolventHCID 7961BromobenzeneSolvent

Procedure

A mixture of 8.2 g of 8-chloro-6-phenyl-1H-s-triazolo[4,3-a][1,5]benzodiazepine-1,5-dione, 5 g of copper powder and 2.5 g of potassium acetate in 100 ml of bromobenzene are refluxed for six hours with stirring. The reaction is diluted with methylene chloride, filtered through a short Florisil column and the filtrate washed with dilute aqueous ammonium hydroxide. The organic phase is washed with water, dried and the solvent evaporated to give the title compound.

Workup

  1. temperatureare refluxed for six hours
  2. filtrationfiltered through a short Florisil column
  3. washthe filtrate washed with dilute aqueous ammonium hydroxide
  4. washThe organic phase is washed with water
  5. customdried
  6. customthe solvent evaporated

Sources & evidence

ORD record
ord-b7ba2fdc3d21464e966fb35f68f77376
Source dataset
uspto-grants-1977_07
Patent number
US04033947

Reaction notes

Loading…