反应详情

A mixture of 2.00g (11.1 mmol) of 2-aminoterephthalic acid, 1.73g (11.1 mmol) of 6-chloronicotinic acid, 2.5ml of conc. HCl and 25ml of ethanol was heated at reflux for 67 hours. The mixture was cooled and filtered to give 0.90g of solid, mp. 275° -324° . The crude material was recrystallized from 1-propanol and gave 0.40g of the mono-esterified product, mp. 283° -293° dec.

1. temperaturewas heated
2. temperatureat reflux for 67 hours
3. temperatureThe mixture was cooled
4. filtrationfiltered