反应详情

温度

0 °C

A mixture of 269 parts of p-bromo-α-methylbenzyl alcohol and 225 parts of 2H-3,4-dihydropyran is stirred and cooled to 0° C. Then there are added dropwise 10 drops of concentrated hydrochloric acid solution and the whole is stirred in an ice-bath (room temperature is reached). After stirring for 24 hours, the reaction mixture is poured onto 1200 parts of ether. The organic phase is washed twice with a sodium hydrogen carbonate solution and twice with water, dried, filtered and evaporated. The residue is distilled, yielding 2-(p-bromo-α-methylbenzyloxy)tetrahydropyran; bp. 165°-177° C. at 20 mm. pressure.

1. stirringthe whole is stirred in an ice-bath (room temperature is reached)
2. stirringAfter stirring for 24 hours
3. washThe organic phase is washed twice with a sodium hydrogen carbonate solution and twice with water
4. customdried
5. filtrationfiltered
6. customevaporated
7. distillationThe residue is distilled