反应详情

Epibromohydrin (1.37 g.) in 2 ml. dry tetrahydrofuran is added to a stirred suspension of the salt obtained by mixing 3 g. of 4-methylbenzyl mercaptan and 550 mg. of sodium hydride (56% dispersion in mineral oil) in 60 ml. dry tetrahydrofuran. The resulting solution is heated at reflux for 4 hours. Thereafter, the solvent is removed and 30 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the ether extracts washed with water, dried over magnesium sulfate and evaporated to dryness to yield 1,3-bis(4'-methylbenzylthio)-2-propanol.

1. customobtained
2. additionby mixing 3 g
3. temperatureThe resulting solution is heated
4. temperatureat reflux for 4 hours
5. customThereafter, the solvent is removed
6. additionof water is added to the residue
7. extractionThe resultant aqueous mixture is extracted with ether
8. washthe ether extracts washed with water
9. dry with materialdried over magnesium sulfate
10. customevaporated to dryness