Benzyl chloride hydrochloride → 5-Benzyloxycarbonyl-6-benzyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

HRID 25955Notes

Reaction equation

HRID 25955 reaction equation
[C:1]([CH:4]1[NH:9][CH2:8][C:7]2[S:10][CH:11]=[CH:12][C:6]=2[CH2:5]1)([OH:3])=[O:2].Cl.[CH2:14](Cl)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)(C)C>[CH2:14]([O:2][C:1]([CH:4]1[N:9]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:8][C:7]2[S:10][CH:11]=[CH:12][C:6]=2[CH2:5]1)=[O:3])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 19596036Benzyl chloride hydrochlorideHCID 23465916HCID 23465916, compound

Product 1

HCID 213259735-Benzyloxycarbonyl-6-benzyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridineYield 53%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Obtained according to a procedure analogous to that of Example 7, from 5-carboxy-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (Example 6) and benzyl chloride. Hydrochloride: pale yellow crystals; M.p. 135°-140° C. (isopropanol); Yield: 53%.

Workup

  1. customObtained

Sources & evidence

ORD record
ord-b671f540aa9b4a5aa48ac542def02e55
Source dataset
uspto-grants-1979_04
Patent number
US04147787

Reaction notes

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