Isopropylamine → HCID 54118625, compound

HRID 259609Notes

Reaction equation

HRID 259609 reaction equation
[CH2:1]([C:4]1[CH:14]=[C:13]([CH:15]=[CH:16][NH:17][C:18]([O:20][CH3:21])=[O:19])[CH:12]=[CH:11][C:5]=1[O:6][CH2:7][CH:8]1[O:10][CH2:9]1)[CH:2]=[CH2:3].[CH:22]([NH2:25])([CH3:24])[CH3:23]>C(O)(C)C>[CH2:1]([C:4]1[CH:14]=[C:13]([CH:15]=[CH:16][NH:17][C:18]([O:20][CH3:21])=[O:19])[CH:12]=[CH:11][C:5]=1[O:6][CH2:7][CH:8]([OH:10])[CH2:9][NH:25][CH:22]([CH3:24])[CH3:23])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 54296525HCID 54296525, compound

Product 1

HCID 54118625HCID 54118625, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4.9 g (0.017 mol) of 1-[2-allyl-4-(2-methoxycarbonylaminovinyl)-phenoxy]-2,3-epoxy-propane are heated for 3 hours with a solution of 1.57 ml (0.018 mol) of isopropylamine in 100 ml of isopropanol to 80° C. under reflux. The mixture is then evaporated under reduced pressure and the resulting crude base is crystallised from acetone-ether. 1-[2-Allyl-4-(2-methoxycarbonylaminovinyl)-phenoxy]-2-hydroxy-3-isopropylamino-propane, of melting point 128°-129° C. is obtained.

Workup

  1. temperatureunder reflux
  2. customThe mixture is then evaporated under reduced pressure
  3. customthe resulting crude base is crystallised from acetone-ether

Sources & evidence

ORD record
ord-42985de8c5af4c5e9cfae0a24a818faa
Source dataset
uspto-grants-1977_07
Patent number
US04038414

Reaction notes

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