Isopropanol → HCID 68118243, compound

HRID 259613Notes

Reaction equation

HRID 259613 reaction equation
[CH3:1][O:2][C:3]1[CH:13]=[C:12]([CH:14]=[CH:15][NH:16][C:17]([O:19][CH3:20])=[O:18])[CH:11]=[CH:10][C:4]=1[O:5][CH2:6][CH:7]1[O:9][CH2:8]1.C([NH2:24])(C)C.[CH:25](O)([CH3:27])[CH3:26]>>[CH3:1][O:2][C:3]1[CH:13]=[C:12]([CH:14]=[CH:15][NH:16][C:17]([O:19][CH3:20])=[O:18])[CH:11]=[CH:10][C:4]=1[O:5][CH:6]([NH2:24])[CH:7]([OH:9])[CH2:8][CH:25]([CH3:27])[CH3:26]

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 6363IsopropylamineHCID 54362627HCID 54362627, compound

Product 1

HCID 68118243HCID 68118243, compound

Procedure

4.2 g (0.015 mol) of 1-[2-methoxy-4-(2-methoxycarbonylaminovinyl)-phenoxy]-2,3-epoxy-propane are heated with a solution of 1.3 ml (0.016 mol) of isopropylamine in 100 ml of isopropanol to 80° C. under reflux for 3 hours. The mixture is then evaporated in vacuo and the resulting crude base is crystallised from acetone-ether. 1-[2-Methoxy-4-(2-methoxycarbonylaminovinyl)-phenoxy]-2-hydroxy-3-isopropyl-aminopropane, of melting point 109°-111° C. is obtained.

Workup

  1. temperatureunder reflux for 3 hours
  2. customThe mixture is then evaporated in vacuo
  3. customthe resulting crude base is crystallised from acetone-ether

Sources & evidence

ORD record
ord-df530a5f574847289a35844c67bead30
Source dataset
uspto-grants-1977_07
Patent number
US04038414

Reaction notes

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