反应详情

A mixture 100 grams (0.438 mole) of 4-phenoxybutyl bromide, 59.5 grams (0.438 mole) of p-hydroxyacetophenone, and 60.4 grams (0.438 mole) of potassium carbonate in approximately 200 milliliters of dry dimethylformamide, is stirred at its reflux temperature for a period of about 4 hours. The reaction mixture is cooled, water added, and the reaction product removed by filtration. The product is washed with a solution of 2 N sodium hydroxide, washed with water, and recrystallized twice from isopropyl alcohol to yield the desired p-(4-phenoxybutoxy) acetophenone having a m.p. of 104°-6° C.

1. temperaturereflux temperature for a period of about 4 hours
2. temperatureThe reaction mixture is cooled
3. customthe reaction product removed by filtration
4. washThe product is washed with a solution of 2 N sodium hydroxide
5. washwashed with water
6. customrecrystallized twice from isopropyl alcohol