反应详情

A mixture of 174.6 grams (1.15 mole) of 3-phenylpropyl thiol, 158.8 grams (1.15 mole) of p-fluoroacetophenone and 158.8 grams (1.15 mole) of potassium carbonate in 500 ml. of dry dimethylformamide is stirred at its reflux temperature for approximately 24 hours. The reaction mixture is cooled, water added and extracted with methylene chloride. The extract is washed with water, a solution of 2 N sodium hydroxide, dried over anhydrous sodium sulfate and evaporated in vacuo. The residue is recrystallized from isopropyl alcohol to yield the desired p-(3-phenylpropylthio)acetophenone having a m.p. of 76°-8° C.

1. temperaturereflux temperature for approximately 24 hours
2. temperatureThe reaction mixture is cooled
3. extractionextracted with methylene chloride
4. washThe extract is washed with water
5. dry with materiala solution of 2 N sodium hydroxide, dried over anhydrous sodium sulfate
6. customevaporated in vacuo
7. customThe residue is recrystallized from isopropyl alcohol