Methyl 2-chloro-3-oxopentanoate → Methyl 3-amino-2-chloro-2-pentenoate

HRID 259799Notes

Reaction equation

HRID 259799 reaction equation
C([O-])=O.[NH4+:4].[Cl:5][CH:6]([C:11](=O)[CH2:12][CH3:13])[C:7]([O:9][CH3:10])=[O:8]>C(O)C>[NH2:4][C:11]([CH2:12][CH3:13])=[C:6]([Cl:5])[C:7]([O:9][CH3:10])=[O:8]

Participants

4

Reactant 2

HCID 545096Methyl 2-chloro-3-oxopentanoateHCID 2723923Ammonium formate

Product 1

HCID 86749529Methyl 3-amino-2-chloro-2-pentenoateYield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 47.5 g (0.75 mol) of ammonium formate and 49.0 g (0.3 mol) of methyl 2-chloro-3-oxovalerate in 800 ml of ethanol is reacted and worked up in analogy to Example 2. Yield: 72.0% [GC]

Sources & evidence

ORD record
ord-0b8c90080f24455b82d46f1bfdd0c91b
Source dataset
uspto-grants-1996_06
Patent number
US05523404

Reaction notes

Loading…