反应详情

7.2 parts of isobutyraldehyde in 15 parts of sodium-dried dioxan was added to a suspension of 25 parts of benzhydrylammonium hypophosphite in 150 parts of sodium-dried dioxan under reflux. 80 Parts of dioxan was removed and 150 parts of alcohol added. After cooling the mixture was filtered to give DL-1-benzhydrylamino-2-methylpropanephosphonous acid, melting point 189°-192° identical to that obtained in Example 2A.

1. temperatureunder reflux
2. custom80 Parts of dioxan was removed
3. addition150 parts of alcohol added
4. temperatureAfter cooling the mixture
5. filtrationwas filtered