反应详情

Valine ethyl ester (0.0028 mol) in 10 ml acetonitrile was reacted with dimethylthiocarbamoyl chloride (0.0056 mol) at 50° C. for 2 hours. Solvent acetonitrile was removed by rotary evaporation. Trifluoroacetic acid (10 ml) was added and the mixture stirred at room temperature for 15 min. The trifluoroacetic acid was removed by rotary evaporation. The residue was dissolved in water and analyzed by FAB/MS. The expected product, dimethylthiocarbamoyl valine (MH+=205), was obtained.

1. customSolvent acetonitrile was removed by rotary evaporation
2. additionTrifluoroacetic acid (10 ml) was added
3. customThe trifluoroacetic acid was removed by rotary evaporation
4. dissolutionThe residue was dissolved in water