反应详情

3-Nitrocinnamic acid (5.0, 25.9 mM) was dissolved in DMF (50 ml), and anhydrous K2CO3 (7.15 g, 51.8 mM) added with stirring. Allyl bromide (3.36 ml, 38.8 mM) was run in, and the mixture stirred for 18 hours at ambient temperature. After filtration, the solvent was evaporated, the residue treated with water, and product extracted into diethyl ether (2 ×100 ml). The organic solution was washed with an aqueous solution of NaHCO3, water, and brine, and dried (MgSO4). Evaporation of the solvent gave title compound (6 g).

1. stirringstirred for 18 hours at ambient temperature
2. filtrationAfter filtration
3. customthe solvent was evaporated
4. additionthe residue treated with water, and product
5. extractionextracted into diethyl ether (2 ×100 ml)
6. washThe organic solution was washed with an aqueous solution of NaHCO3, water, and brine
7. dry with materialdried (MgSO4)
8. customEvaporation of the solvent