反应详情

4.1 g of 2,4,6-trimethylphenol was dissolved in 15 ml of dichloromethane, and 4.2 ml of triethylamine was added while stirring the solution. Further, 4.6 g of 3-chlorosulfonyl-1,2,4-triazole was gradually added while being cooled with ice and stirred. Then, the solution was stirred at room temperature for 14 hours. After that, 2N hydrochloric acid was added to separate the components. The organic layer was washed with water, and then it was dried with magnesium sulfate. Then, the solvent was removed by distillation, so that coarse crystals were obtained. The coarse crystals were recrystallized from n-hexane/ethyl acetate, so that 3.0 g of the titled compound was obtained.

1. temperaturewhile being cooled with ice
2. stirringstirred
3. stirringThen, the solution was stirred at room temperature for 14 hours
4. customto separate the components
5. washThe organic layer was washed with water
6. dry with materialit was dried with magnesium sulfate
7. customThen, the solvent was removed by distillation
8. customso that coarse crystals were obtained
9. customThe coarse crystals were recrystallized from n-hexane/ethyl acetate, so that 3.0 g of the titled compound
10. customwas obtained