Hydrogen Peroxide → HCID 178527335, compound

HRID 260350Notes

Reaction equation

HRID 260350 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[N:14]=[CH:13][NH:12][N:11]=2)=[CH:5][CH:4]=1.OO.[OH2:19].S([O-])([O-])(=[O:22])=S.[Na+].[Na+]>C(O)(=O)C>[F:16][C:2]([F:15])([F:1])[C:3]1[CH:8]=[CH:7][C:6]([S:9]([C:10]2[N:14]=[CH:13][NH:12][N:11]=2)(=[O:22])=[O:19])=[CH:5][CH:4]=1

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 24477Sodium ThiosulfateHCID 178506225HCID 178506225, compound

Product 1

HCID 178527335HCID 178527335, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

76.4 g of 3-[4-(trifluoromethyl)phenylthio]-1,2,4-triazole synthesized by a method similar to that employed to prepare the precursor according to Reference Example 4 was dissolved in 400 ml of acetic acid, and 140 g of 30% hydrogen peroxide solution was added. Then, the temperature was gradually raised, and the solution was stirred at 100° C. for three hours. Then, the reactant solution was cooled to room temperature, and a water solution of sodium thiosulfate was added. Then, precipitate was filtered, so that 66.4 g of the titled compound was obtained (at a yield of 77%).

Workup

  1. customto prepare the precursor
  2. temperatureThen, the temperature was gradually raised
  3. temperatureThen, the reactant solution was cooled to room temperature
  4. filtrationThen, precipitate was filtered, so that 66.4 g of the titled compound
  5. customwas obtained (at a yield of 77%)

Sources & evidence

ORD record
ord-25a0876016f54ba289b0e131539213b9
Source dataset
uspto-grants-1996_06
Patent number
US05527818

Reaction notes

Loading…