HCID 10090620, compound → HCID 22175770, compound

HRID 260451Notes

Reaction equation

HRID 260451 reaction equation
CS(O[CH2:6][C:7]1[N:8]([CH3:26])[C:9](=[O:25])[C:10]2[C:15]([C:16]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[CH:14][C:13]([CH3:23])=[C:12]([CH3:24])[CH:11]=2)(=O)=O.[NH3:27].CO>C1COCC1>[NH2:27][CH2:6][C:7]1[N:8]([CH3:26])[C:9](=[O:25])[C:10]2[C:15]([C:16]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[CH:14][C:13]([CH3:23])=[C:12]([CH3:24])[CH:11]=2

Participants

4

Reactant 2

HCID 10090620HCID 10090620, compoundHCID 21705897Ammonia methanol

Product 1

HCID 22175770HCID 22175770, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of the compound (0.68 g) obtained in Step 1, THF (20 ml) and 15% ammonia/methanol (20 ml) was heated for 20 hours at 140° C. in a sealed tube. The solvent was distilled off. To the residue was added ethyl acetate, and the mixture was washed with an aqueous solution of potassium carbonate and water, successively, then dried (MgSO4). The solvent was distilled off to leave the title compound as colorless crystals (0.37 g),

Workup

  1. distillationThe solvent was distilled off
  2. additionTo the residue was added ethyl acetate
  3. washthe mixture was washed with an aqueous solution of potassium carbonate and water
  4. dry with materialsuccessively, then dried (MgSO4)
  5. distillationThe solvent was distilled off

Sources & evidence

ORD record
ord-c734db55c62644d9af6e76b1236db002
Source dataset
uspto-grants-1996_06
Patent number
US05527811

Reaction notes

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