Acetic Acid → HCID 21463115, compound

HRID 260452Notes

Reaction equation

HRID 260452 reaction equation
C(C[C:4]1[N:5]([CH3:23])[C:6](=[O:22])[C:7]2[C:12]([C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:11][C:10]([CH3:20])=[C:9]([CH3:21])[CH:8]=2)#N.Cl.[C:25]([OH:28])(=[O:27])[CH3:26]>>[CH3:23][N:5]1[C:4]([CH2:26][C:25]([OH:28])=[O:27])=[C:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:12]2[C:7](=[CH:8][C:9]([CH3:21])=[C:10]([CH3:20])[CH:11]=2)[C:6]1=[O:22]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 21463171HCID 21463171, compound

Product 1

HCID 21463115HCID 21463115, compound

Conditions

Temperature
110 °C

Procedure

A mixture of the compound (4.7 g) obtained in Step 1, acetic acid (150 ml) and hydrochloric acid (150 ml) was heated for 7 hours at 110° C. The solvent was distilled off. To the residue was added ethyl acetate, which was washed with water and dried (MgSO4), then the solvent was distilled off to leave the title compound as colorless crystals (3.7 g).

Workup

  1. distillationThe solvent was distilled off
  2. additionTo the residue was added ethyl acetate, which
  3. washwas washed with water
  4. dry with materialdried (MgSO4)
  5. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-6f3cfaa10d444bd880f6a3a330145591
Source dataset
uspto-grants-1996_06
Patent number
US05527811

Reaction notes

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