1,4-Dibromobutane → 1-Methyl-6,7,8,9-tetrahydropyrazolo[3',4':4,5]pyrimido[2,1-b]-[1,3]thiazepin-4(1H)-one

HRID 260523Notes

Reaction equation

[SH:1][C:2]1[NH:3][C:4](=[O:12])[C:5]2[CH:10]=[N:9][N:8]([CH3:11])[C:6]=2[N:7]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][CH2:21][CH2:22][CH2:23]Br>CN(C)C=O>[CH3:11][N:8]1[C:6]2[N:7]=[C:2]3[N:3]([C:4](=[O:12])[C:5]=2[CH:10]=[N:9]1)[CH2:23][CH2:22][CH2:21][CH2:20][S:1]3

Participants

Conditions

Temperature: 80 °C

Procedure

In 120 ml of dimethylformamide was dissolved 6.0 g (32.9 mmol) of 4,5-dihydro-6-mercapto-1-methylpyrazolo[3,4-d]pyrimidin-4(1H)-one [Helv. Chim. Acta, 42, 349 (1959)], and 13.7 g (98.8 mmol) of potassium carbonate and 5.90 ml (49.4 mmol) of 1,4-dibromobutane were added to the solution, followed by stirring at 80° C. for 6 hours. After evaporation of the solvent, the residue was subjected to partition between chloroform and water, and the chloroform layer was concentrated to dryness under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with chloroform to give 1.71 g (22%) of Compound 45. The compound was recrystallized from ethanol for purification.

Workup

additionwere added to the solution
customAfter evaporation of the solvent
customto partition between chloroform and water
concentrationthe chloroform layer was concentrated to dryness under reduced pressure
washeluted with chloroform

Sources & evidence

ORD record: ord-14f49c318af843eaadb79bd83c555c11
Source dataset: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05527908

Reaction notes

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