1-butylindole-3-carboxylic Acid → Indole-3-Carboxylic Acid

HRID 260534Notes

Reaction equation

HRID 260534 reaction equation
C([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]([OH:16])=[O:15])=[CH:6]1)CCC>[Pd]>[NH:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]([OH:16])=[O:15])=[CH:6]1

Participants

3

Reactant 1

HCID 103762901-butylindole-3-carboxylic Acid

Product 1

HCID 69867Indole-3-Carboxylic Acid

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

reacting the 4-bromomethyl-2'-[2-(1-methyl-1-phenylethyl)-2H-tetrasol-5-yl]biphenyl with 2-transmetalated 1-but-1-yl-1H-indole-3-carboxylic acid in the presence of phosphinated palladium catalyst to give 1-butyl-2-[2'-92-(1-methyl-1-phenylethyl)-2H-tetrasol-5-yl)biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid; and

Sources & evidence

ORD record
ord-6e79d3253feb40d1b677e849f6165dca
Source dataset
uspto-grants-1996_06
Patent number
US05527918

Reaction notes

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