反应详情

Dissolve 1-(carboethoxy)-1-(4-methoxybenzylthio)cyclopropane (0.310 g, 1.16 mmol) in 95% ethanol (6 mL), water (3 mL), and tetrahydrofuran (6 mL). Treat with lithium hydroxide monohydrate (420 mg, 10mmol). Stir at a gentle reflux for 6 hours and evaporate the solvent in vacuo. Add water (50 mL) and wash with ether (50 mL). Acidify the aqueous phase and extract into methylene chloride (50 mL). Dry (Na2SO4) and evaporate the solvent in vacuo to give 1-(carboxy)-1-(4-methoxybenzylthio)cyclopropane as a pale yellow solid (266 mg).

1. temperaturea gentle reflux for 6 hours
2. customevaporate the solvent in vacuo
3. washAdd water (50 mL) and wash with ether (50 mL)
4. extractionextract into methylene chloride (50 mL)
5. dry with materialDry (Na2SO4)
6. customevaporate the solvent in vacuo