Hydrochloric Acid → HCID 11790735, compound

HRID 260824Notes

Reaction equation

HRID 260824 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:16])[CH2:12][CH2:13][CH2:14][CH3:15])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[BH4-].[Na+].Cl>CC(O)C>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]([OH:16])[CH2:12][CH2:13][CH2:14][CH3:15])=[CH:9][CH:10]=1)[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 109984904'-Isobutylpentanophenone

Product 1

HCID 11790735HCID 11790735, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 4'-isobutylvalerophenone in 2-propanol was added sodium borohydride, and the mixture was stirred at 50° C. for 5 hours. The reaction mixture was poured into ice water, acidified with 6N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate and concentrated to give the object compound.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated
  5. customto give the object compound

Sources & evidence

ORD record
ord-e1abd3fb9bc348d0a663d1130b134bf4
Source dataset
uspto-grants-1996_06
Patent number
US05530019

Reaction notes

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