反应详情

A mixture of 3-[8-(4-isobutylphenyl)undecanoyl]indole obtained in Pre. Ex. 8 (62 mg), ethyl 4-bromobutyrate (58 mg) and potassium carbonate (62 mg) in N,N-dimethylformamide (2 ml) was stirred at room temperature for 16 hours. After filtration, the solution was diluted with ethyl acetate, washed with water and brine, dried over magnesium sulfate and concentrated. The residue was chromatographed on a silica gel column (hexane-ethyl acetate, 4: 1) to give ethyl 4-[3-[8-(4-isobutylphenyl)-undecanoyl]-1-indolyl]butyrate as an oil. (48 mg)

1. customobtained in Pre
2. filtrationAfter filtration
3. additionthe solution was diluted with ethyl acetate
4. washwashed with water and brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated
7. customThe residue was chromatographed on a silica gel column (hexane-ethyl acetate, 4: 1)