4-Fluorophenol → HCID 12772646, compound

HRID 261038Notes

Reaction equation

HRID 261038 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[C:5]([OH:10])=[C:4]([CH2:11]O)[CH:3]=1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1>Cl.C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:11][C:18]2[CH:19]=[C:14]([F:13])[CH:15]=[CH:16][C:17]=2[OH:20])[C:5]([OH:10])=[C:6]([CH2:8][C:18]2[CH:19]=[C:14]([F:13])[CH:15]=[CH:16][C:17]=2[OH:20])[CH:7]=1

Participants

5

Reactant 2

HCID 97324-FluorophenolHCID 869144-Chloro-2,6-bis(hydroxymethyl)phenol

Product 1

HCID 12772646HCID 12772646, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 241BenzeneSolvent2×

Procedure

A mixture of 4-chloro-2,6-bis(hydroxymethyl)phenol (4.8 g), 4-fluorophenol (16.0 g), benzene (25 ml) and hydrochloric acid (5 drops) was heated on a boiling water bath until all the benzene had evaporated. On cooling the mixture deposited colourless crystals of 4-chloro-2,6-bis(5-fluoro-2-hydroxybenzyl)phenol (11.9 g), mp 228° C.

Workup

  1. customhad evaporated
  2. temperatureOn cooling the mixture

Sources & evidence

ORD record
ord-87520f8986e24a8ea199f6d604d28991
Source dataset
uspto-grants-1979_08
Patent number
US04163801

Reaction notes

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