Acetone → HCID 13064236, compound

HRID 261047Notes

Reaction equation

[Br:1][C:2]1[C:3]([OH:28])=[C:4]([CH:24]=[C:25]([Cl:27])[CH:26]=1)[CH2:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]([CH2:13][C:14]2[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Br:21])[C:15]=2O)[C:7]=1O.[C:29](=[O:32])([O-])[O-].[K+].[K+].S([O:40][CH3:41])(OC)(=O)=O.[CH3:42]C(C)=O>>[Br:21][C:16]1[C:15]([O:32][CH3:29])=[C:14]([CH:19]=[C:18]([Cl:20])[CH:17]=1)[CH2:13][C:8]1[CH:9]=[C:10]([F:12])[CH:11]=[C:6]([CH2:5][C:4]2[CH:24]=[C:25]([Cl:27])[CH:26]=[C:2]([Br:1])[C:3]=2[O:28][CH3:42])[C:7]=1[O:40][CH3:41]

Participants

Reactant 4

HCID 180Acetone

HCID 6497Dimethyl Sulfate

HCID 11430Potassium Carbonate

HCID 5251690HCID 5251690, compound

Product 1

HCID 13064236HCID 13064236, compound

Procedure

A mixture of 2,6-bis(3-bromo-5-chloro-2-hydroxybenzyl)-4-fluorophenol (10 g), potassium carbonate (10 g) and dimethyl sulphate (7 g) in acetone (250 ml) was heated under reflux for 12 hr. The title compound was isolated and purified by column chromatography; m.p. c. 75°.

Workup

temperaturewas heated
temperatureunder reflux for 12 hr

Sources & evidence

ORD record: ord-54b52bf9fcbc40ac8f6f40446df0e8b8
Source dataset: uspto-grants-1979_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04163801

Reaction notes

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