反应详情

A stirred suspension of 6-chloro-2-(1-piperazinyl)-pyrazine hydrochloride (2.35 g, 10.0 mmol) and 2.8 g potassium carbonate in 25 ml of acetonitrile at 50° C. is treated with 0.9 ml (10.4 mmol) allylbromide. After 4 hours at 50° C. the mixture is concentrated under vacuum and the residue partitioned between water and chloroform. The chloroform extract is chromatographed on silica gel. Elution with 1% methanol-chloroform gives fractions containing 0.4 g (15%) title salt, mp 233.5°-234° C. by treatment with hydrogen chloride in ethanol-isopropanol.

1. concentrationAfter 4 hours at 50° C. the mixture is concentrated under vacuum
2. customthe residue partitioned between water and chloroform
3. extractionThe chloroform extract
4. customis chromatographed on silica gel
5. washElution with 1% methanol-chloroform
6. customgives fractions