1-[3-(acetylthio)-2-tert-butoxycarbonylaminomethylpropanoyl]-L-proline tert-butyl ester → 1-(3-acetylthio-2-aminomethylpropanoyl)-L-proline

HRID 261339노트

반응식

HRID 261339 반응식
C([O:5][C:6](=[O:29])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:28])[CH:13]([CH2:19][NH:20]C(OC(C)(C)C)=O)[CH2:14][S:15][C:16](=[O:18])[CH3:17])(C)(C)C>C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>[C:16]([S:15][CH2:14][CH:13]([CH2:19][NH2:20])[C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([OH:29])=[O:5])=[O:28])(=[O:18])[CH3:17]

참가 물질

4

반응물 1

HCID 228053301-[3-(acetylthio)-2-tert-butoxycarbonylaminomethylpropanoyl]-L-proline tert-butyl ester

생성물 1

HCID 537828151-(3-acetylthio-2-aminomethylpropanoyl)-L-proline

시약·촉매·용매 2

HCID 6422Trifluoroacetic acid용매HCID 7519Anisole용매

실험 절차

1-[3-(acetylthio)-2-tert-butyloxycarbonylaminomethyl-propanoyl]-L-proline tert-butyl ester (1.5 g) is dissolved in a mixture of anisole (6 ml) and trifluoroacetic acid (12 ml) and the solution is stored at room temperature for one hour. The solvent is removed in vacuo, the residue is distributed between water and ether. The aqueous phase is washed twice with ether and freeze-dried to yield 1-(3-acetylthio-2-aminomethylpropanoyl)-L-proline.

후처리

  1. customThe solvent is removed in vacuo
  2. washThe aqueous phase is washed twice with ether
  3. customfreeze-dried

출처 및 근거

ORD 기록
ord-2d091016069848d2b9e7ff29ce660c94
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04165320

반응 노트

불러오는 중…